What is it?
This is a steroid enema in the form of a liquid containing prednisolone 20 mg.

What is it used for?
It is used in the treatment of ulcerative colitis and is usually given at night time. The enema is retained in the bowel acting directly on the inflamed tissue. It is used in the treatment of left-sided colitis or rectal inflammation.

How do I use it?
For the best results, you should be on your left side in bed with the end of the bed propped up if possible to help you hold the enema in better. Lubricate and insert the applicator through the anus and up into the rectum. Squeeze the bag gently ensuring all the liquid is expelled. Ideally it is held in the bowel overnight and any residual liquid will be passed when going to the toilet in the morning. However, if this is not possible, you should try and hold the liquid in for at least one hour so that it can act with effect on the inflamed area.

• It should not cause you to have a bowel motion but you may find it difficult to hold if your bowel is very inflamed.
• It may help to warm the enemas before use by immersing the unopened container in a jug of warm water.
• To ensure that the enema reaches as high as possible, it will help to roll over on to your other side once the fluid is instilled into the rectum.

Are there any precautions?
You should not use this enema if you have a bowel infection.

Predsol can be used with caution during pregnancy if the doctor feels that the benefits outweigh any potential hazards.

Are there any side effects?
Side effects are relatively rare as the steroid drug acts locally on the site of inflammation and very little is absorbed into the body. However, it may cause similar effects to those of steroids taken by mouth, such as:
• High blood pressure
• Diabetes
• Osteoporosis
• Mood changes
• Weight gain

Other preparations of Predsol
Predsol suppositories - used in treatment of proctitis and anal complications of Crohn's disease. The same precautions apply. The suppositories are to be inserted morning and evening after having the bowels opened. Length of treatment will be determined by the doctor but will usually be for approximately one month.